Pathology Overview: Key Concepts in Systemic Pathology Pathology Overview: Key Concepts in Systemic Pathology Published: 2025-12-25T00:00:00.000Z Pathology is the bridge between basic science and clinical decision-making. Understanding the mechanisms of injury, inflammation, repair and neoplasia allows clinicians to interpret laboratory and histology results, generate appropriate differential diagnoses, and guide management. This overview focuses on high‑yield concepts and practical study strategies for students and early clinicians. Essential mechanisms Begin with the cellular response to injury. Reversible injury causes cell swelling and loss of function; irreversible injury leads to necrosis or apoptosis. The inflammatory response—innate and adaptive—determines tissue outcomes: resolution, chronic inflammation, or fibrosis. Learn the cardinal signs and cellular players for both acute and chronic inflammation. Repair, healing and clinical ...
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